What is Amyloidosis?

Context

  • Recently, former Pakistan President has been hospitalized due to a complication of his ailment Amyloidosis.

What is Amyloidosis?

  • A rare disease that occurs when an abnormal protein, called amyloid, builds up in one’s organs, affecting their shape and functioning.

    Amyloidosis
    Photo Credit: Wikipedia
  • Amyloid deposits can build up in the heart, brain, kidneys, spleen and other parts of the body, leading to life-threatening conditions like organ failure.
  • Amyloid isn’t normally found in the body, but can be formed from several different types of proteins.
  • Some varieties of amyloidosis occur in association with other diseases.
  • These types may improve with treatment of the underlying disease.
  • Some varieties of amyloidosis may lead to life-threatening organ failure.
  • It may be secondary to a different health condition or can develop as a primary condition as well.
  • Sometimes, it is due to a mutation in a gene, but usually, the cause of it remains unknown.

Cause

  • Many different proteins can lead to amyloid deposits, but only a few lead to major health problems.
  • The type of protein and where it collects tell the type of amyloidosis one has.
  • Amyloid deposits may collect throughout one’s body or in just one area.

Treatment

  • There is not currently a cure for the disease.
  • The amyloid deposits cannot be directly removed. But there are treatments to stop more of the abnormal proteins being produced and treat your symptoms.
  • These treatments can give your body time to gradually clear the deposits before they build up again. This can help prevent organ damage.

Reference:

https://indianexpress.com/article/explained/explained-what-is-amyloidosis-7963439/

https://www.news18.com/news/explainers/amyloidosis-is-a-rare-disease-that-occurs-when-an-abnormal-protein-builds-up-in-organs-and-interferes-with-the-normal-function-5350075.html


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